San Francisco walked away from Week 1 of the 2025 season with a 17-13 win vs. the Seahawks. However, two starters have suffered long-term injuries that will significantly impact the team.
Earlier this week, NFL insiders reported that All-Pro TE George Kittle was placed on the IR. He suffered a hamstring strain in Week 1. Jauan Jennings suffered a shoulder injury, but he is expected to be back soon. However, San Francisco was hit with tough injury news ahead of their Week 2 matchup. Starting QB Brock Purdy has turf toe and is out at least 2-5 weeks for the 49ers. That’s unfortunate injury luck early in the year.
How many games will Brock Purdy miss for the 49ers?
From @GMFB: #Commanders QB Jayden Daniels (wrist) is off the injury report, while #49ers QB Brock Purdy is out 2-5 weeks with a turf toe variant, sources say. pic.twitter.com/xQPT3Jm3cS
— Ian Rapoport (@RapSheet) September 11, 2025
The 49ers cannot catch a break just one week into the 2025 NFL season. Not only will the team be without their starting TE in Week 2, but they’ll also miss the services of starting QB Brock Purdy. On Wednesday, head coach Kyle Shanahan said Purdy was a “long shot” to play in Week 2 vs. the Saints. As of Thursday morning, the reports on Purdy have not improved. NFL insiders reported that Purdy is dealing with a variant of turf toe.
Ian Rapoport of the NFL Network said Purdy is expected to miss two to five weeks. That means Brock Purdy will be out at least two games for San Francisco. He’ll miss Week 2 vs. the Saints and Week 3 vs. the Cardinals. Purdy could miss more time depending on how quickly he recovers. Not ideal for the 49ers to start the new season.
BREAKING: 49ers QB Brock Purdy is expected to be out 2-5 weeks with a turf toe variant, per @RapSheet.
Mac Jones is in line to get the start in place of Purdy for Week 2. pic.twitter.com/gs5yZhelAI
— Yahoo Sports (@YahooSports) September 11, 2025
With Purdy out this Sunday vs. the Saints, backup QB Mac Jones will start his first game for San Francisco. This offseason, Jones landed with the 49ers after a year with the Jacksonville Jaguars. Jones was the 15th pick in the 2021 NFL draft by the Patriots. Over three seasons, Jones played in 42 games and made 42 starts for New England.
After Trevor Lawrence suffered a season-ending injury in 2024, Jones started the final seven weeks for the Jaguars. He went 2-5 as a starter for the Jacksonville. Now, he’ll have another opportunity to start at least two consecutive games for the 49ers. Brocky Purdy is out due to turf toe. Can Mac Jones keep San Francisco’s offense running smoothly while Purdy misses time? His first test is this Sunday on the road vs. the Saints.
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